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TargetCathepsin (B and K)
LigandBDBM19782
Substrate/Competitorn/a
Meas. Tech.ChEMBL_216562
Ki 59±n/a nM
Citation Marquis RWRu YLoCastro SMZeng JYamashita DSOh HJErhard KFDavis LDTomaszek TATew DSalyers KProksch JWard KSmith BLevy MCummings MDHaltiwanger RCTrescher GWang BHemling MEQuinn CJCheng HYLin FSmith WWJanson CAZhao BMcQueney MSD'Alessio KLee CPMarzulli ADodds RABlake SHwang SMJames IEGress CJBradley BRLark MWGowen MVeber DF Azepanone-based inhibitors of human and rat cathepsin K. J Med Chem 44:1380-95 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Cathepsin (B and K)
Name:Cathepsin (B and K)
Synonyms:APP secretase | APPS | Cathepsin B | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:Enzyme
Mol. Mass.:37819.69
Organism:Homo sapiens (Human)
Description:gi_63102437
Residue:339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM19782
n/a
NameBDBM19782
Synonyms:(2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(2S)-3-oxo-4-(pyridine-2-sulfonamido)butan-2-yl]pentanamide | CHEMBL31545 | ketone, 1
TypeSmall organic molecule
Emp. Form.C24H28N4O6S
Mol. Mass.500.567
SMILESCC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@@H](C)C(=O)CNS(=O)(=O)c1ccccn1 |r|
Structure
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