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TargetC-C chemokine receptor type 1
LigandBDBM50098630
Substrate/Competitorn/a
Meas. Tech.ChEMBL_220711
IC50 17±n/a nM
Citation Naya ASagara YOhwaki KSaeki TIchikawa DIwasawa YNoguchi KOhtake N Design, synthesis, and discovery of a novel CCR1 antagonist. J Med Chem 44:1429-35 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
C-C chemokine receptor type 1
Name:C-C chemokine receptor type 1
Synonyms:C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CD_antigen=CD191 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R
Type:Enzyme
Mol. Mass.:41180.69
Organism:Homo sapiens (Human)
Description:P32246
Residue:355
Sequence:
METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLV
QYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTH
HTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRL
IFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVI
YAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
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  Blast E-value cutoff:
BDBM50098630
n/a
NameBDBM50098630
Synonyms:1-Cyclooctylmethyl-4-[(2,7-dichloro-9H-xanthene-9-carbonyl)-amino]-1-methyl-piperidinium; iodide | CHEMBL33929
TypeSmall organic molecule
Emp. Form.C29H37Cl2N2O2
Mol. Mass.516.522
SMILESC[N+]1(CC2CCCCCCC2)CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2ccc(Cl)cc12 |(9.02,-6.84,;9.03,-8.38,;10.37,-9.15,;11.94,-8.48,;11.34,-7.06,;11.94,-5.63,;13.36,-5.04,;14.77,-5.63,;15.37,-7.06,;14.77,-8.47,;13.36,-9.06,;7.68,-7.65,;6.36,-8.38,;6.36,-9.92,;7.71,-10.69,;9.06,-9.92,;5.04,-10.69,;3.7,-9.92,;3.69,-8.38,;2.39,-10.69,;1.06,-9.92,;1.06,-8.38,;-.28,-7.61,;-.29,-6.07,;-1.63,-8.38,;-1.6,-9.95,;-.29,-10.69,;-.31,-12.23,;1.04,-13,;1.03,-14.53,;2.35,-15.31,;3.7,-14.54,;5.18,-14.95,;3.7,-13.03,;2.39,-12.23,)|
Structure
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