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TargetC-C chemokine receptor type 1
LigandBDBM50098634
Substrate/Competitorn/a
Meas. Tech.ChEMBL_220711
IC50 14±n/a nM
Citation Naya ASagara YOhwaki KSaeki TIchikawa DIwasawa YNoguchi KOhtake N Design, synthesis, and discovery of a novel CCR1 antagonist. J Med Chem 44:1429-35 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
C-C chemokine receptor type 1
Name:C-C chemokine receptor type 1
Synonyms:C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CD_antigen=CD191 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R
Type:Enzyme
Mol. Mass.:41180.69
Organism:Homo sapiens (Human)
Description:P32246
Residue:355
Sequence:
METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLV
QYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTH
HTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRL
IFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVI
YAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
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  Blast E-value cutoff:
BDBM50098634
n/a
NameBDBM50098634
Synonyms:1-Cyclooctylmethyl-1-methyl-4-[(9H-xanthene-9-carbonyl)-amino]-piperidinium; iodide | CHEMBL34165
TypeSmall organic molecule
Emp. Form.C29H39N2O2
Mol. Mass.447.6316
SMILESC[N+]1(CC2CCCCCCC2)CCC(CC1)NC(=O)C1c2ccccc2Oc2ccccc12 |(5.5,2.52,;5.66,.6,;7.01,-.17,;8.57,.51,;7.97,1.93,;8.57,3.36,;9.99,3.95,;11.4,3.36,;12,1.95,;11.4,.51,;9.99,-.08,;4.31,1.35,;2.99,.6,;2.99,-.94,;4.34,-1.71,;5.69,-.94,;1.68,-1.73,;.36,-.96,;.33,.58,;-.98,-1.73,;-.98,-3.27,;.33,-4.05,;.33,-5.58,;-1.02,-6.35,;-2.33,-5.56,;-2.33,-4.04,;-3.65,-3.27,;-3.65,-1.73,;-4.96,-.97,;-4.99,.58,;-3.65,1.35,;-2.3,.58,;-2.3,-.96,)|
Structure
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