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TargetSubstance-P receptor
LigandBDBM50099554
Substrate/Competitorn/a
Meas. Tech.ChEBML_141778
IC50 0.120000±n/a nM
Citation Dinnell, KChicchi, GGDhar, MJElliott, JMHollingworth, GJKurtz, MMRidgill, MPRycroft, WTsao, KLWilliams, ARSwain, CJ 2-Aryl indole NK1 receptor antagonists: optimisation of the 2-aryl ring and the indole nitrogen substituent. Bioorg Med Chem Lett11:1237-40 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Substance-P receptor
Name:Substance-P receptor
Synonyms:NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:46254.43
Organism:Homo sapiens (Human)
Description:P25103
Residue:407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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  Blast E-value cutoff:
BDBM50099554
n/a
NameBDBM50099554
Synonyms:1-(4-Benzyl-4-hydroxy-piperidin-1-yl)-3-[5-chloro-1-methyl-2-(5-trifluoromethyl-pyridin-2-yl)-1H-indol-3-yl]-propan-1-one | CHEMBL21792
TypeSmall organic molecule
Emp. Form.C30H29ClF3N3O2
Mol. Mass.556.018
SMILESCn1c(c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc12)-c1ccc(cn1)C(F)(F)F
Structure
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