Reaction Details |
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Target | Substance-P receptor |
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Ligand | BDBM50099554 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_141778 |
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IC50 | 0.120000±n/a nM |
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Citation | Dinnell, K; Chicchi, GG; Dhar, MJ; Elliott, JM; Hollingworth, GJ; Kurtz, MM; Ridgill, MP; Rycroft, W; Tsao, KL; Williams, AR; Swain, CJ 2-Aryl indole NK1 receptor antagonists: optimisation of the 2-aryl ring and the indole nitrogen substituent. Bioorg Med Chem Lett11:1237-40 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Substance-P receptor |
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Name: | Substance-P receptor |
Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46254.43 |
Organism: | Homo sapiens (Human) |
Description: | P25103 |
Residue: | 407 |
Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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BDBM50099554 |
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n/a |
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Name | BDBM50099554 |
Synonyms: | 1-(4-Benzyl-4-hydroxy-piperidin-1-yl)-3-[5-chloro-1-methyl-2-(5-trifluoromethyl-pyridin-2-yl)-1H-indol-3-yl]-propan-1-one | CHEMBL21792 |
Type | Small organic molecule |
Emp. Form. | C30H29ClF3N3O2 |
Mol. Mass. | 556.018 |
SMILES | Cn1c(c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc12)-c1ccc(cn1)C(F)(F)F |
Structure |
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