| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-K receptor |
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| Ligand | BDBM50099644 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_209033 (CHEMBL818108) |
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| Ki | 4.2±n/a nM |
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| Citation |  Blaney, FE; Raveglia, LF; Artico, M; Cavagnera, S; Dartois, C; Farina, C; Grugni, M; Gagliardi, S; Luttmann, MA; Martinelli, M; Nadler, GM; Parini, C; Petrillo, P; Sarau, HM; Scheideler, MA; Hay, DW; Giardina, GA Stepwise modulation of neurokinin-3 and neurokinin-2 receptor affinity and selectivity in quinoline tachykinin receptor antagonists. J Med Chem44:1675-89 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-K receptor |
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| Name: | Substance-K receptor |
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| Synonyms: | NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3 |
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| Type: | Protein |
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| Mol. Mass.: | 44455.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21452 |
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| Residue: | 398 |
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| Sequence: | MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILA
HRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATK
CVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLR
HLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSST
MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMA
GDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
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| BDBM50099644 |
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| n/a |
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| Name | BDBM50099644 |
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| Synonyms: | 3-(4-Isopropyl-piperazin-1-ylmethyl)-2-phenyl-quinoline-4-carboxylic acid cyclohexylamide | CHEMBL45362 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H38N4O |
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| Mol. Mass. | 470.6489 |
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| SMILES | CC(C)N1CCN(Cc2c(nc3ccccc3c2C(=O)NC2CCCCC2)-c2ccccc2)CC1 |
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| Structure | 
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