| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Urokinase-type plasminogen activator |
|---|
| Ligand | BDBM50099925 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_213135 |
|---|
| Ki | 641±n/a nM |
|---|
| Citation |  Subasinghe, NL; Illig, C; Hoffman, J; Rudolph, MJ; Wilson, KJ; Soll, R; Randle, T; Green, D; Lewandowski, F; Zhang, M; Bone, R; Spurlino, J; DesJarlais, R; Deckman, I; Molloy, CJ; Manthey, C; Zhou, Z; Sharp, C; Maguire, D; Crysler, C; Grasberger, B Structure-based design, synthesis and SAR of a novel series of thiopheneamidine urokinase plasminogen activator inhibitors. Bioorg Med Chem Lett11:1379-82 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Urokinase-type plasminogen activator |
|---|
| Name: | Urokinase-type plasminogen activator |
|---|
| Synonyms: | PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator/surface receptor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 48528.62 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00749 |
|---|
| Residue: | 431 |
|---|
| Sequence: | MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
YCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII
GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG
RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML
CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR
SHTKEENGLAL
|
|
|
|---|
| BDBM50099925 |
|---|
| n/a |
|---|
| Name | BDBM50099925 |
|---|
| Synonyms: | 4-(4-Cyclohexyl-thiazol-2-yl)-5-methylsulfanyl-thiophene-2-carboxamidine | CHEMBL283859 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H19N3S3 |
|---|
| Mol. Mass. | 337.526 |
|---|
| SMILES | CSc1sc(cc1-c1nc(cs1)C1CCCCC1)C(N)=N |
|---|
| Structure | 
|
|---|
Search and Browse
