| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor tyrosine-protein kinase erbB-2 |
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| Ligand | BDBM50099971 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_194950 (CHEMBL795906) |
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| IC50 | 26±n/a nM |
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| Citation |  Cockerill, S; Stubberfield, C; Stables, J; Carter, M; Guntrip, S; Smith, K; McKeown, S; Shaw, R; Topley, P; Thomsen, L; Affleck, K; Jowett, A; Hayes, D; Willson, M; Woollard, P; Spalding, D Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2. Bioorg Med Chem Lett11:1401-5 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor tyrosine-protein kinase erbB-2 |
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| Name: | Receptor tyrosine-protein kinase erbB-2 |
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| Synonyms: | ERBB2_RAT | Erbb2 | Neu | Receptor protein-tyrosine kinase erbB-2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 138816.81 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_42235 |
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| Residue: | 1257 |
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| Sequence: | MELAAWCRWGFLLALLPPGIAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNL
ELTYVPANASLSFLQDIQEVQGYMLIAHNQVKRVPLQRLRIVRGTQLFEDKYALAVLDNR
DPQDNVAASTPGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQDMVLWKDVFRKNNQL
APVDIDTNRSRACPPCAPACKDNHCWGESPEDCQILTGTICTSGCARCKGRLPTDCCHEQ
CAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMHNPEGRYTFGASCVTTC
PYNYLSTEVGSCTLVCPPNNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLRGARAITSD
NVQEFDGCKKIFGSLAFLPESFDGDPSSGIAPLRPEQLQVFETLEEITGYLYISAWPDSL
RDLSVFQNLRIIRGRILHDGAYSLTLQGLGIHSLGLRSLRELGSGLALIHRNAHLCFVHT
VPWDQLFRNPHQALLHSGNRPEEDLCVSSGLVCNSLCAHGHCWGPGPTQCVNCSHFLRGQ
ECVEECRVWKGLPREYVSDKRCLPCHPECQPQNSSETCFGSEADQCAACAHYKDSSSCVA
RCPSGVKPDLSYMPIWKYPDEEGICQPCPINCTHSCVDLDERGCPAEQRASPVTFIIATV
VGVLLFLILVVVVGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKET
ELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVG
SPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLED
VRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRR
FTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKC
WMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPSSPMDSTFYRSLLEDDDMGDLV
DAEEYLVPQQGFFSPDPTPGTGSTAHRRHRSSSTRSGGGELTLGLEPSEEGPPRSPLAPS
EGAGSDVFDGDLAMGVTKGLQSLSPHDLSPLQRYSEDPTLPLPPETDGYVAPLACSPQPE
YVNQSEVQPQPPLTPEGPLPPVRPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLV
PREGTASPPHPSPAFSPAFDNLYYWDQNSSEQGPPPSNFEGTPTAENPEYLGLDVPV
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| BDBM50099971 |
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| n/a |
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| Name | BDBM50099971 |
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| Synonyms: | CHEMBL288557 | N*4*-(1-Benzyl-1H-indol-5-yl)-pyrido[3,4-d]pyrimidine-4,6-diamine |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18N6 |
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| Mol. Mass. | 366.4185 |
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| SMILES | Nc1cc2c(Nc3ccc4n(Cc5ccccc5)ccc4c3)ncnc2cn1 |
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| Structure | 
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