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TargetDual specificity mitogen-activated protein kinase kinase 1
LigandBDBM50099983
Substrate/Competitorn/a
Meas. Tech.ChEMBL_60730
IC50 4.2±n/a nM
Citation Zhang NWu BEudy NWang YYe FPowell DWissner AFeldberg LRKim SCMallon RKovacs EDToral-Barza LKohler CA MEK (MAPKK) inhibitors. Part 2: structure-activity relationships of 4-anilino-3-cyano-6,7-dialkoxyquinolines. Bioorg Med Chem Lett 11:1407-10 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Dual specificity mitogen-activated protein kinase kinase 1
Name:Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase
Synonyms:Dual specificity mitogen-activated protein kinase (MEK) | Dual specificity mitogen-activated protein kinase kinase 1 (MEK) | Dual specificity mitogen-activated protein kinase kinase 1 (MEK1) | Dual specificity mitogen-activated protein kinase kinase MEK1/2 | ERK activator kinase 1 | MAP kinase kinase 1 | MAPK/ERK kinase 1 | MAPK/ERK kinase 1 (MEK1) | MEK-1 | Mitogen-activated protein kinase 1 (MEK1)
Type:Other Protein Type
Mol. Mass.:43439.03
Organism:Homo sapiens (Human)
Description:Full-length human MEK-1 was generated by PCR and purified as a fusion protein from Escherichia coli lysates.
Residue:393
Sequence:
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
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  Blast E-value cutoff:
BDBM50099983
n/a
NameBDBM50099983
Synonyms:6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-thiophen-3-ylmethyl-phenylamino)-quinoline-3-carbonitrile | CHEMBL30359
TypeSmall organic molecule
Emp. Form.C29H30N4O3S
Mol. Mass.514.639
SMILESCOc1cc2c(Nc3ccc(Cc4ccsc4)cc3)c(cnc2cc1OCCCN1CCOCC1)C#N
Structure
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