| Reaction Details |
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 | Report a problem with these data |
| Target | Tryptase beta-2/delta/gamma |
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| Ligand | BDBM50101011 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_210696 (CHEMBL817294) |
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| Ki | 0.850000±n/a nM |
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| Citation |  Dener, JM; Rice, KD; Newcomb, WS; Wang, VR; Young, WB; Gangloff, AR; Kuo, EY; Cregar, L; Putnam, D; Wong, M Dibasic inhibitors of human mast cell tryptase. Part 3: identification of a series of potent and selective inhibitors containing the benzamidine functionality. Bioorg Med Chem Lett11:1629-33 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tryptase beta-2/delta/gamma |
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| Name: | Tryptase beta-2/delta/gamma |
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| Synonyms: | Tryptase |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 1510505 |
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| Components: | This complex has 3 components. |
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| Component 1 |
| Name: | Tryptase gamma |
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| Synonyms: | PRSS31 | Serine protease 31 | TMT | TPSG1 | TRYG1_HUMAN | Transmembrane tryptase | Tryptase | Tryptase gamma | Tryptase gamma heavy chain | Tryptase gamma light chain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 33817.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_210833 |
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| Residue: | 321 |
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| Sequence: | MALGACGLLLLLAVPGVSLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRM
HVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITLSPHFSTVRQIILHSSPSGQP
GTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLR
EVKVSVVDTETCRRDYPGPGGSILQPDMLCARGPGDACQDDSGGPLVCQVNGAWVQAGTV
SWGEGCGRPNRPGVYTRVPAYVNWIRRHITASGGSESGYPRLPLLAGLFLPGLFLLLVSC
VLLAKCLLHPSADGTPFPAPD
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| Component 2 |
| Name: | Tryptase beta-2 |
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| Synonyms: | TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30518.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_210702 |
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| Residue: | 275 |
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| Sequence: | MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCG
GSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGA
DIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKV
PIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAG
VVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
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| Component 3 |
| Name: | Tryptase delta |
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| Synonyms: | Delta-tryptase | HmMCP-3-like tryptase III | Mast cell mMCP-7-like | TPSD1 | TRYD_HUMAN | Tryptase delta | Tryptase-3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 26578.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_104777 |
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| Residue: | 242 |
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| Sequence: | MLLLAPQMLSLLLLALPVLASPAYVAPAPGQALQQTGIVGGQEAPRSKWPWQVSLRVRGP
YWMHFCGGSLIHPQWVLTAAHCVEPDIKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQF
YIIQTGADIALLELEEPVNISSHIHTVTLPPASETFPPGMPCWVTGWGDVDNNVHLPPPY
PLKEVEVPVVENHLCNAEYHTGLHTGHSFQIVRDDMLCAGSENHDSCQGDSGGPLVCKVN
GT
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| BDBM50101011 |
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| n/a |
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| Name | BDBM50101011 |
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| Synonyms: | 1,5-di{4-[4-amino(imino)methylphenylcarboxamidomethyl]hexahydro-1-pyridinylcarbonyloxy}cyclooctane | CHEMBL43938 |
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| Type | Small organic molecule |
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| Emp. Form. | C38H52N8O6 |
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| Mol. Mass. | 716.8695 |
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| SMILES | NC(=N)c1ccc(cc1)C(=O)NCC1CCN(CC1)C(=O)O[C@H]1CCC[C@H](CCC1)OC(=O)N1CCC(CNC(=O)c2ccc(cc2)C(N)=N)CC1 |
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| Structure | 
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