| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidine kinase |
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| Ligand | BDBM50101062 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_210611 |
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| IC50 | 1.5±n/a nM |
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| Citation |  Martin, JA; Lambert, RW; Merrett, JH; Parkes, KE; Thomas, GJ; Baker, SJ; Bushnell, DJ; Cansfield, JE; Dunsdon, SJ; Freeman, AC; Hopkins, RA; Johns, IR; Keech, E; Simmonite, H; Walmsley, A; Wong Kai-In, P; Holland, M Nucleoside analogues as highly potent and selective inhibitors of herpes simplex virus thymidine kinase. Bioorg Med Chem Lett11:1655-8 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidine kinase |
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| Name: | Thymidine kinase |
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| Synonyms: | KITH_HHV1S | TK | Thymidine kinase | UL23 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40883.42 |
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| Organism: | Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1) |
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| Description: | ChEMBL_213 |
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| Residue: | 376 |
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| Sequence: | MASYPGHQHASAFDQAARSRGHSNRRTALRPRRQQEATEVRPEQKMPTLLRVYIDGPHGM
GKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASETIANIYTTQHRLDQGEISAGDAAVV
MTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMG
SMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYG
LLANTVRYLQGGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPELLAP
NGDLYNVFAWALDVLAKRLRPMHVFILDYDQSPAGCRDALLQLTSGMIQTHVTTPGSIPT
ICDLARTFAREMGEAN
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| BDBM50101062 |
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| n/a |
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| Name | BDBM50101062 |
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| Synonyms: | 4-Chloro-9H-thioxanthene-9-carboxylic acid [(2R,3R,4S,5R)-5-(5-ethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-tetrahydro-furan-2-ylmethyl]-amide | CHEMBL295657 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23ClFN3O5S |
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| Mol. Mass. | 531.984 |
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| SMILES | CCc1cn([C@@H]2O[C@H](CNC(=O)C3c4ccccc4Sc4c(Cl)cccc34)[C@@H](O)[C@@H]2F)c(=O)[nH]c1=O |
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| Structure | 
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