Reaction Details |
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Target | Endothelin-1 receptor |
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Ligand | BDBM50101247 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_65627 |
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IC50 | 77±n/a nM |
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Citation | Kukkola, PJ; Bilci, NA; Ikler, T; Savage, P; Shetty, SS; DelGrande, D; Jeng, AY Isoindolines: a new series of potent and selective endothelin-A receptor antagonists. Bioorg Med Chem Lett11:1737-40 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Endothelin-1 receptor |
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Name: | Endothelin-1 receptor |
Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 48736.88 |
Organism: | Homo sapiens (Human) |
Description: | P25101 |
Residue: | 427 |
Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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BDBM50101247 |
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n/a |
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Name | BDBM50101247 |
Synonyms: | CHEMBL49850 | [(1R,3S)-1-Benzo[1,3]dioxol-5-yl-5-ethoxy-3-(2-hydroxy-4-methoxy-phenyl)-1,3-dihydro-isoindol-2-yl]-acetic acid |
Type | Small organic molecule |
Emp. Form. | C26H25NO7 |
Mol. Mass. | 463.4792 |
SMILES | CCOc1ccc2[C@H](N(CC(O)=O)[C@@H](c2c1)c1ccc(OC)cc1O)c1ccc2OCOc2c1 |
Structure |
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