| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50101249 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_65627 |
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| IC50 | 31±n/a nM |
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| Citation |  Kukkola, PJ; Bilci, NA; Ikler, T; Savage, P; Shetty, SS; DelGrande, D; Jeng, AY Isoindolines: a new series of potent and selective endothelin-A receptor antagonists. Bioorg Med Chem Lett11:1737-40 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48736.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25101 |
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| Residue: | 427 |
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| Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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| BDBM50101249 |
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| n/a |
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| Name | BDBM50101249 |
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| Synonyms: | CHEMBL301371 | {2-[(1S,3R)-3-Benzo[1,3]dioxol-5-yl-6-ethoxy-2-(1H-tetrazol-5-yl)-2,3-dihydro-1H-isoindol-1-yl]-5-methoxy-phenoxy}-acetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C27H25N5O7 |
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| Mol. Mass. | 531.5167 |
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| SMILES | CCOc1ccc2[C@H](N([C@@H](c2c1)c1ccc(OC)cc1OCC(O)=O)c1nnn[nH]1)c1ccc2OCOc2c1 |
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| Structure | 
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