| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor VII/Tissue factor |
|---|
| Ligand | BDBM50103652 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_69535 (CHEMBL680624) |
|---|
| Ki | 5±n/a nM |
|---|
| Citation |  Young, WB; Kolesnikov, A; Rai, R; Sprengeler, PA; Leahy, EM; Shrader, WD; Sangalang, J; Burgess-Henry, J; Spencer, J; Elrod, K; Cregar, L Optimization of a screening lead for factor VIIa/TF. Bioorg Med Chem Lett11:2253-6 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor VII/Tissue factor |
|---|
| Name: | Coagulation factor VII/Tissue factor |
|---|
| Synonyms: | Coagulation factor III/Factor VIIa (fVIIa) | Coagulation factor III/VII |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of EBI is 69535 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Tissue factor |
|---|
| Synonyms: | CD_antigen=CD142 | Coagulation factor III | Coagulation factor VII/tissue factor | F3 | TF | TF_HUMAN | Thromboplastin | Tissue factor |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 33067.61 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_936735 |
|---|
| Residue: | 295 |
|---|
| Sequence: | METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPK
PVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGS
AGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFG
KDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVE
CMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS
|
|
|
|---|
| Component 2 |
| Name: | Coagulation factor VII |
|---|
| Synonyms: | Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 51599.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 466 |
|---|
| Sequence: | MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
|
|
|
|---|
| BDBM50103652 |
|---|
| n/a |
|---|
| Name | BDBM50103652 |
|---|
| Synonyms: | 5-(5-Carbamimidoyl-1H-indol-2-yl)-6-hydroxy-3'-nitro-biphenyl-3-carboxylic acid | CHEMBL307381 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H16N4O5 |
|---|
| Mol. Mass. | 416.3862 |
|---|
| SMILES | NC(=N)c1ccc2[nH]c(cc2c1)-c1cc(cc(c1O)-c1cccc(c1)[N+]([O-])=O)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
