Reaction Details |
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Target | Muscarinic acetylcholine receptor M2 |
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Ligand | BDBM50103767 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_139750 |
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Ki | 0.290000±n/a nM |
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Citation | Boyle, CD; Chackalamannil, S; Clader, JW; Greenlee, WJ; Josien, HB; Kaminski, JJ; Kozlowski, JA; McCombie, SW; Nazareno, DV; Tagat, JR; Wang, Y; Zhou, G; Billard, W; Binch, H; Crosby, G; Cohen-Williams, M; Coffin, VL; Cox, KA; Grotz, DE; Duffy, RA; Ruperto, V; Lachowicz, JE Metabolic stabilization of benzylidene ketal M(2) muscarinic receptor antagonists via halonaphthoic acid substitution. Bioorg Med Chem Lett11:2311-4 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M2 |
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Name: | Muscarinic acetylcholine receptor M2 |
Synonyms: | ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2 |
Type: | GPCR |
Mol. Mass.: | 51730.61 |
Organism: | Homo sapiens (Human) |
Description: | P08172 |
Residue: | 466 |
Sequence: | MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
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BDBM50103767 |
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n/a |
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Name | BDBM50103767 |
Synonyms: | (5,8-Difluoro-naphthalen-1-yl)-(4-{2-[4-(4-methoxy-benzenesulfonyl)-phenyl]-[1,3]dioxolan-2-yl}-[1,4']bipiperidinyl-1'-yl)-methanone | CHEMBL308787 |
Type | Small organic molecule |
Emp. Form. | C37H38F2N2O6S |
Mol. Mass. | 676.769 |
SMILES | COc1ccc(cc1)S(=O)(=O)c1ccc(cc1)C1(OCCO1)C1CCN(CC1)C1CCN(CC1)C(=O)c1cccc2c(F)ccc(F)c12 |
Structure |
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