| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine--tRNA ligase, cytoplasmic |
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| Ligand | BDBM50104310 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_211023 |
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| IC50 | 124±n/a nM |
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| Citation |  Jarvest, RL; Berge, JM; Houge-Frydrych, CS; Mensah, LM; O'Hanlon, PJ; Pope, AJ Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of carbocyclic analogues of the natural product SB-219383. Bioorg Med Chem Lett11:2499-502 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine--tRNA ligase, cytoplasmic |
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| Name: | Tyrosine--tRNA ligase, cytoplasmic |
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| Synonyms: | SYYC_HUMAN | Tyrosyl-tRNA synthetase | YARS | YARS1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59145.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_211030 |
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| Residue: | 528 |
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| Sequence: | MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIA
DFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKG
TDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVD
AQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKED
VKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFA
AEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEP
EEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLV
VVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEE
LKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS
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| BDBM50104310 |
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| n/a |
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| Name | BDBM50104310 |
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| Synonyms: | (R)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-((1S,4S,5S,6S)-4,5,6-trihydroxy-cyclohex-2-enyl)-acetic acid ethyl ester | CHEMBL82579 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H26N2O7 |
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| Mol. Mass. | 394.4189 |
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| SMILES | CCOC(=O)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H]1C=C[C@H](O)[C@H](O)[C@H]1O |c:21| |
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| Structure | 
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