Reaction Details |
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Target | Tyrosine--tRNA ligase, cytoplasmic |
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Ligand | BDBM18128 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_211023 |
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IC50 | 0.600000±n/a nM |
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Citation | Jarvest, RL; Berge, JM; Houge-Frydrych, CS; Mensah, LM; O'Hanlon, PJ; Pope, AJ Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of carbocyclic analogues of the natural product SB-219383. Bioorg Med Chem Lett11:2499-502 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine--tRNA ligase, cytoplasmic |
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Name: | Tyrosine--tRNA ligase, cytoplasmic |
Synonyms: | SYYC_HUMAN | Tyrosyl-tRNA synthetase | YARS | YARS1 |
Type: | PROTEIN |
Mol. Mass.: | 59145.78 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_211030 |
Residue: | 528 |
Sequence: | MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIA
DFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKG
TDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVD
AQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKED
VKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFA
AEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEP
EEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLV
VVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEE
LKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS
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BDBM18128 |
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n/a |
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Name | BDBM18128 |
Synonyms: | (2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-2-[(1S,3S,4S,5R,8R)-2,4,5,8-tetrahydroxy-7-oxa-2-azabicyclo[3.2.1]octan-3-yl]acetic acid | CHEMBL310012 | SB-219383 |
Type | Small organic molecule |
Emp. Form. | C17H23N3O9 |
Mol. Mass. | 413.3792 |
SMILES | [H][C@]1([C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(O)=O)[C@H](O)[C@]2(O)CO[C@@H]([C@@H]2O)N1O |r| |
Structure |
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