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TargetMacrophage metalloelastase
LigandBDBM50104715
Substrate/Competitorn/a
Meas. Tech.ChEMBL_106458 (CHEMBL719130)
Ki 300±n/a nM
Citation Schröder, J; Henke, A; Wenzel, H; Brandstetter, H; Stammler, HG; Stammler, A; Pfeiffer, WD; Tschesche, H Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold. J Med Chem44:3231-43 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Macrophage metalloelastase
Name:Macrophage metalloelastase
Synonyms:HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12)
Type:Enzyme
Mol. Mass.:54012.99
Organism:Homo sapiens (Human)
Description:P39900
Residue:470
Sequence:
MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50104715
n/a
NameBDBM50104715
Synonyms:(S)-2-(phenylsulfonamido)-N-(5-(4-(trifluoromethyl)phenyl)-6H-1,3,4-thiadiazin-2-yl)propanamide | 2-Benzenesulfonylamino-N-[5-(4-trifluoromethyl-phenyl)-6H-[1,3,4]thiadiazin-2-yl]-propionamide | CHEMBL109770
TypeSmall organic molecule
Emp. Form.C19H17F3N4O3S2
Mol. Mass.470.488
SMILESC[C@H](NS(=O)(=O)c1ccccc1)C(=O)NC1=NN=C(CS1)c1ccc(cc1)C(F)(F)F |c:18,t:16|
Structure
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