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TargetEndothelin receptor ET-A
LigandBDBM50105026
Substrate/Competitorn/a
Meas. Tech.ChEMBL_65802
IC50 0.018±n/a nM
Citation Morimoto HShimadzu HKushiyama EKawanishi HHosaka TKawase YYasuda KKikkawa KYamauchi-Kohno RYamada K Potent and selective ET-A antagonists. 1. Syntheses and structure-activity relationships of N-(6-(2-(aryloxy)ethoxy)-4-pyrimidinyl)sulfonamide derivatives. J Med Chem 44:3355-68 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Endothelin receptor ET-A
Name:Endothelin receptor ET-A
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:48707.29
Organism:Sus scrofa
Description:ChEMBL_65803
Residue:427
Sequence:
METFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERS
SHKDSIN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50105026
n/a
NameBDBM50105026
Synonyms:CHEMBL115724 | N-[6-[2-(5-Bromo-pyrimidin-2-yloxy)-ethoxy]-5-(2-methoxy-phenylsulfanyl)-pyrimidin-4-yl]-4-tert-butyl-benzenesulfonamide
TypeSmall organic molecule
Emp. Form.C27H28BrN5O5S2
Mol. Mass.646.576
SMILESCOc1ccccc1Sc1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ncnc1OCCOc1ncc(Br)cn1
Structure
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