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TargetEndothelin-1 receptor
LigandBDBM50105043
Substrate/Competitorn/a
Meas. Tech.ChEMBL_65802 (CHEMBL679705)
IC50 1.9±n/a nM
Citation Morimoto, HShimadzu, HKushiyama, EKawanishi, HHosaka, TKawase, YYasuda, KKikkawa, KYamauchi-Kohno, RYamada, K Potent and selective ET-A antagonists. 1. Syntheses and structure-activity relationships of N-(6-(2-(aryloxy)ethoxy)-4-pyrimidinyl)sulfonamide derivatives. J Med Chem44:3355-68 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Endothelin-1 receptor
Name:Endothelin-1 receptor
Synonyms:EDNRA | EDNRA_PIG | Endothelin receptor ET-A
Type:PROTEIN
Mol. Mass.:48707.29
Organism:Sus scrofa
Description:ChEMBL_65803
Residue:427
Sequence:
METFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERS
SHKDSIN
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BDBM50105043
n/a
NameBDBM50105043
Synonyms:1,2,3,4-Tetrahydro-fluoren-9-one salt ofN-{6-[2-(5-Bromo-pyrimidin-2-yloxy)-ethoxy]-5-p-tolyl-pyrimidin-4-yl}-4-chloro-benzenesulfonamide | CHEMBL175931
TypeSmall organic molecule
Emp. Form.C23H19BrClN5O4S
Mol. Mass.576.85
SMILESCc1ccc(cc1)-c1c(NS(=O)(=O)c2ccc(Cl)cc2)ncnc1OCCOc1ncc(Br)cn1
Structure
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