Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetIntercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2
LigandBDBM50105196
Substrate/Competitorn/a
Meas. Tech.ChEMBL_89057
IC50 4±n/a nM
Citation Zhu GDArendsen DLGunawardana IWBoyd SAStewart AOFry DGCool BLKifle LSchaefer VMeuth JMarsh KCKempf-Grote AJKilgannon PGallatin WMOkasinski GF Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides. J Med Chem 44:3469-87 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2
Name:Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2
Synonyms:CD_antigen=CD54 | ICAM-1 | Intercellular adhesion molecule 1 | Intercellular adhesion molecule-1 | Major group rhinovirus receptor
Type:PROTEIN
Mol. Mass.:57831.10
Organism:Homo sapiens (Human)
Description:ChEMBL_826675
Residue:532
Sequence:
MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGI
ETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAP
LPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHH
GANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLD
GLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQE
TLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKA
TPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQ
AWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYE
IVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50105196
n/a
NameBDBM50105196
Synonyms:4-{4-[2-(2-Methoxy-ethoxy)-ethoxymethyl]-phenoxy}-thieno[2,3-c]pyridine-2-carboxylic acid amide | CHEMBL117746
TypeSmall organic molecule
Emp. Form.C20H22N2O5S
Mol. Mass.402.464
SMILESCOCCOCCOCc1ccc(Oc2cncc3sc(cc23)C(N)=O)cc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: