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TargetIntercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2
LigandBDBM50105227
Substrate/Competitorn/a
Meas. Tech.ChEMBL_89057
IC50 1.4±n/a nM
Citation Zhu GDArendsen DLGunawardana IWBoyd SAStewart AOFry DGCool BLKifle LSchaefer VMeuth JMarsh KCKempf-Grote AJKilgannon PGallatin WMOkasinski GF Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides. J Med Chem 44:3469-87 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2
Name:Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2
Synonyms:CD_antigen=CD54 | ICAM-1 | Intercellular adhesion molecule 1 | Intercellular adhesion molecule-1 | Major group rhinovirus receptor
Type:PROTEIN
Mol. Mass.:57831.10
Organism:Homo sapiens (Human)
Description:ChEMBL_826675
Residue:532
Sequence:
MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGI
ETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAP
LPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHH
GANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLD
GLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQE
TLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKA
TPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQ
AWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYE
IVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50105227
n/a
NameBDBM50105227
Synonyms:4-[4-(Tetrahydro-pyran-2-yloxymethyl)-phenoxy]-thieno[2,3-c]pyridine-2-carboxylic acid amide | CHEMBL118113
TypeSmall organic molecule
Emp. Form.C20H20N2O4S
Mol. Mass.384.449
SMILESNC(=O)c1cc2c(Oc3ccc(COC4CCCCO4)cc3)cncc2s1
Structure
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