| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Telomerase reverse transcriptase |
|---|
| Ligand | BDBM50105462 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_210227 (CHEMBL808432) |
|---|
| IC50 | 12200±n/a nM |
|---|
| Citation |  West, C; Francis, R; Friedman, SH Small molecule/nucleic acid affinity chromatography: application for the identification of telomerase inhibitors which target its key RNA/DNA heteroduplex. Bioorg Med Chem Lett11:2727-30 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Telomerase reverse transcriptase |
|---|
| Name: | Telomerase reverse transcriptase |
|---|
| Synonyms: | EST2 | TCS1 | TERT | TERT_HUMAN | TRT |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 127099.03 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1447029 |
|---|
| Residue: | 1132 |
|---|
| Sequence: | MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPW
DARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVR
SYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGA
ATQARPPPHASGPRRRLGCERAWNHSVREAGVPLGLPAPGARRRGGSASRSLPLPKRPRR
GAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVG
RQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSLRPSLTGARRL
VETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVT
PAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGS
RHNERRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGVGCVPAAEHRLREEI
LAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRE
LSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKA
LFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTI
PQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHL
QETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTL
LCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNL
RKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTF
NRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLP
FHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLL
KLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTILD
|
|
|
|---|
| BDBM50105462 |
|---|
| n/a |
|---|
| Name | BDBM50105462 |
|---|
| Synonyms: | CHEMBL81880 | N,N,N',N'-Tetramethyl-acridine-3,6-diamine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H19N3 |
|---|
| Mol. Mass. | 265.3529 |
|---|
| SMILES | CN(C)c1ccc2cc3ccc(cc3nc2c1)N(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
