| Reaction Details |
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 | Report a problem with these data |
| Target | Telomerase reverse transcriptase |
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| Ligand | BDBM50105463 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_210225 (CHEMBL816665) |
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| IC50 | 3300±n/a nM |
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| Citation |  West, C; Francis, R; Friedman, SH Small molecule/nucleic acid affinity chromatography: application for the identification of telomerase inhibitors which target its key RNA/DNA heteroduplex. Bioorg Med Chem Lett11:2727-30 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Telomerase reverse transcriptase |
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| Name: | Telomerase reverse transcriptase |
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| Synonyms: | EST2 | TCS1 | TERT | TERT_HUMAN | TRT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 127099.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1447029 |
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| Residue: | 1132 |
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| Sequence: | MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPW
DARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVR
SYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGA
ATQARPPPHASGPRRRLGCERAWNHSVREAGVPLGLPAPGARRRGGSASRSLPLPKRPRR
GAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVG
RQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSLRPSLTGARRL
VETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVT
PAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGS
RHNERRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGVGCVPAAEHRLREEI
LAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRE
LSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKA
LFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTI
PQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHL
QETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTL
LCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNL
RKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTF
NRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLP
FHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLL
KLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTILD
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| BDBM50105463 |
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| n/a |
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| Name | BDBM50105463 |
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| Synonyms: | 2,7-diamino-10-ethyl-9-phenylphenanthridinium bromide | 2,7-diamino-9-phenyl-10-ethylphenanthridinium bromide | 3,8-diamino-5-ethyl-6-phenylphenanthridinium bromide | CHEMBL284328 | Dromilac | EtBr | Ethidium bromide | Homidium bromide |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20N3 |
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| Mol. Mass. | 314.4031 |
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| SMILES | CCn1c(-c2ccccc2)c2cc(N)ccc2c2ccc(=[NH2+])cc12 |
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| Structure | 
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