| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50105687 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_205835 (CHEMBL810946) |
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| EC50 | >25000±n/a nM |
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| Citation |  Lavoie, R; Bouchain, G; Frechette, S; Woo, SH; Abou-Khalil, E; Leit, S; Fournel, M; Yan, PT; Trachy-Bourget, MC; Beaulieu, C; Li, Z; Besterman, J; Delorme, D Design and synthesis of a novel class of histone deacetylase inhibitors. Bioorg Med Chem Lett11:2847-50 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50105687 |
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| n/a |
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| Name | BDBM50105687 |
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| Synonyms: | (E)-N-Hydroxy-3-[4-(2,4,5-triisopropyl-benzenesulfonylamino)-phenyl]-acrylamide | CHEMBL316457 | N-hydroxy-3-(4-(2,4,5-triisopropylphenylsulfonamido)phenyl)acrylamide |
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| Type | Small organic molecule |
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| Emp. Form. | C24H32N2O4S |
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| Mol. Mass. | 444.587 |
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| SMILES | CC(C)c1cc(C(C)C)c(cc1C(C)C)S(=O)(=O)Nc1ccc(\C=C\C(=O)NO)cc1 |
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| Structure | 
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