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TargetPotassium voltage-gated channel subfamily E/KQT member 1
LigandBDBM50106229
Substrate/Competitorn/a
Meas. Tech.ChEMBL_158552 (CHEMBL768695)
IC50 1200±n/a nM
Citation Gerlach, UBrendel, JLang, HJPaulus, EFWeidmann, KBrüggemann, ABusch, AESuessbrich, HBleich, MGreger, R Synthesis and activity of novel and selective I(Ks)-channel blockers. J Med Chem44:3831-7 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Potassium voltage-gated channel subfamily E/KQT member 1
Name:Potassium voltage-gated channel subfamily E/KQT member 1
Synonyms:Voltage-gated potassium channel beta subunit Mink/subunit Kv7.1 | Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK)
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of EBI is 158552
Components:This complex has 2 components.
Component 1
Name:Potassium voltage-gated channel subfamily E member 1
Synonyms:Delayed rectifier potassium channel subunit IsK | IKs producing slow voltage-gated potassium channel subunit beta Mink | KCNE1 | KCNE1_HUMAN | KCNQ1(Kv7.1)/KCNE1(MinK) | Minimal potassium channel | Voltage-gated potassium channel beta subunit Mink | Voltage-gated potassium channel, IKs
Type:PROTEIN
Mol. Mass.:14676.11
Organism:Homo sapiens (Human)
Description:ChEMBL_1456351
Residue:129
Sequence:
MILSNTTAVTPFLTKLWQETVQQGGNMSGLARRSPRSSDGKLEALYVLMVLGFFGFFTLG
IMLSYIRSKKLEHSNDPFNVYIESDAWQEKDKAYVQARVLESYRSCYVVENHLAIEQPNT
HLPETKPSP
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Component 2
Name:Potassium voltage-gated channel subfamily KQT member 1
Synonyms:KCNA8 | KCNA9 | KCNQ (Kv7) potassium channel | KCNQ1 | KCNQ1_HUMAN | KVLQT1 | Voltage-gated potassium channel subunit Kv7.1 | Voltage-gated potassium channel subunit Kv7.1/Misshapen-like kinase 1
Type:PROTEIN
Mol. Mass.:74739.00
Organism:Homo sapiens (Human)
Description:ChEMBL_1454245
Residue:676
Sequence:
MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGALYAPIAPGAPG
PAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLERPTGW
KCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGC
RSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLH
VDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYA
DALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQR
QKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKK
KKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFM
RTNSFAEDLDLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRD
VIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVT
QLDQRLALITDMLHQLLSLHGGSTPGSGGPPREGGAHITQPCGSGGSVDPELFLPSNTLP
TYEQLTVPRRGPDEGS
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BDBM50106229
n/a
NameBDBM50106229
Synonyms:CHEMBL127435 | Ethanesulfonic acid (6-fluoro-3-hydroxy-2,2-dimethyl-chroman-4-yl)-methyl-amide
TypeSmall organic molecule
Emp. Form.C14H20FNO4S
Mol. Mass.317.376
SMILESCCS(=O)(=O)N(C)C1C(O)C(C)(C)Oc2ccc(F)cc12
Structure
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