Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetVoltage-gated potassium channel beta subunit Mink/subunit Kv7.1
LigandBDBM50106230
Substrate/Competitorn/a
Meas. Tech.ChEMBL_158552
IC50 6900±n/a nM
Citation Gerlach UBrendel JLang HJPaulus EFWeidmann KBrüggemann ABusch AESuessbrich HBleich MGreger R Synthesis and activity of novel and selective I(Ks)-channel blockers. J Med Chem 44:3831-7 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Voltage-gated potassium channel beta subunit Mink/subunit Kv7.1
Name:Voltage-gated potassium channel beta subunit Mink/subunit Kv7.1
Synonyms:Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK)
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of EBI is 158552
Components:This complex has 2 components.
Component 1
Name:Voltage-gated potassium channel beta subunit Mink
Synonyms:Delayed rectifier potassium channel subunit IsK | IKs producing slow voltage-gated potassium channel subunit beta Mink | KCNQ1(Kv7.1)/KCNE1(MinK) | Minimal potassium channel | Voltage-gated potassium channel, IKs
Type:PROTEIN
Mol. Mass.:14676.11
Organism:Homo sapiens (Human)
Description:ChEMBL_1456351
Residue:129
Sequence:
MILSNTTAVTPFLTKLWQETVQQGGNMSGLARRSPRSSDGKLEALYVLMVLGFFGFFTLG
IMLSYIRSKKLEHSNDPFNVYIESDAWQEKDKAYVQARVLESYRSCYVVENHLAIEQPNT
HLPETKPSP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 2
Name:KCNQ (Kv7) potassium channel
Synonyms:Voltage-gated potassium channel subunit Kv7.1
Type:PROTEIN
Mol. Mass.:74739.00
Organism:Homo sapiens (Human)
Description:ChEMBL_1454245
Residue:676
Sequence:
MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGALYAPIAPGAPG
PAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLERPTGW
KCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGC
RSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLH
VDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYA
DALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQR
QKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKK
KKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFM
RTNSFAEDLDLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRD
VIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVT
QLDQRLALITDMLHQLLSLHGGSTPGSGGPPREGGAHITQPCGSGGSVDPELFLPSNTLP
TYEQLTVPRRGPDEGS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50106230
n/a
NameBDBM50106230
Synonyms:CHEMBL338273 | Ethanesulfonic acid (6-cyano-3-hydroxy-2,2-dimethyl-chroman-4-yl)-methyl-amide
TypeSmall organic molecule
Emp. Form.C15H20N2O4S
Mol. Mass.324.395
SMILESCCS(=O)(=O)N(C)C1C(O)C(C)(C)Oc2ccc(cc12)C#N
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: