| Reaction Details |
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 | Report a problem with these data |
| Target | Tissue-type plasminogen activator |
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| Ligand | BDBM50106239 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_222779 (CHEMBL847108) |
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| Ki | 350±n/a nM |
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| Citation |  Mackman, RL; Katz, BA; Breitenbucher, JG; Hui, HC; Verner, E; Luong, C; Liu, L; Sprengeler, PA Exploiting subsite S1 of trypsin-like serine proteases for selectivity: potent and selective inhibitors of urokinase-type plasminogen activator. J Med Chem44:3856-71 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tissue-type plasminogen activator |
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| Name: | Tissue-type plasminogen activator |
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| Synonyms: | Alteplase | PLAT | Reteplase | TPA_HUMAN | Thrombin receptor protein | Tissue-type plasminogen activator | Tissue-type plasminogen activator (tPA) | Tissue-type plasminogen activator precursor | t-PA | t-Plasminogen Activator (tPA) | t-plasminogen activator |
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| Type: | Enzyme |
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| Mol. Mass.: | 62931.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 562 |
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| Sequence: | MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV
LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR
NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN
SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
DVPGVYTKVTNYLDWIRDNMRP
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| BDBM50106239 |
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| n/a |
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| Name | BDBM50106239 |
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| Synonyms: | 6-Fluoro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-carboxamidine | CHEMBL127909 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H16FN3O |
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| Mol. Mass. | 345.3696 |
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| SMILES | NC(=N)c1cc2cc([nH]c2cc1F)-c1cccc(-c2ccccc2)c1O |
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| Structure | 
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