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TargetEndothelin-1 receptor
LigandBDBM50056081
Substrate/Competitorn/a
Meas. Tech.ChEMBL_63341 (CHEMBL679283)
IC50 1.2±n/a nM
Citation Jae, HSWinn, Mvon Geldern, TWSorensen, BKChiou, WJNguyen, BMarsh, KCOpgenorth, TJ Pyrrolidine-3-carboxylic acids as endothelin antagonists. 5. Highly selective, potent, and orally active ET(A) antagonists. J Med Chem44:3978-84 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Endothelin-1 receptor
Name:Endothelin-1 receptor
Synonyms:EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:48256.91
Organism:RAT
Description:ENDOTHELIN A EDNRA RAT::P26684
Residue:426
Sequence:
MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCM
LNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSS
HKDSMN
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  Blast E-value cutoff:
BDBM50056081
n/a
NameBDBM50056081
Synonyms:(2R,3R,4S)-1-Dibutylcarbamoylmethyl-4-(2,3-dihydro-benzofuran-6-yl)-2-(4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid | 1-Dibutylcarbamoylmethyl-4-(2,3-dihydro-benzofuran-6-yl)-2-(4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid | CHEMBL326191
TypeSmall organic molecule
Emp. Form.C30H40N2O5
Mol. Mass.508.649
SMILESCCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(OC)cc1)C(O)=O)c1ccc2CCOc2c1
Structure
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