Reaction Details |
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Target | Methylated-DNA--protein-cysteine methyltransferase |
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Ligand | BDBM50106511 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_103719 (CHEMBL712287) |
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IC50 | 32±n/a nM |
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Citation | Reinhard, J; Hull, WE; von der Lieth, CW; Eichhorn, U; Kliem, HC; Kaina, B; Wiessler, M Monosaccharide-linked inhibitors of O(6)-methylguanine-DNA methyltransferase (MGMT): synthesis, molecular modeling, and structure-activity relationships. J Med Chem44:4050-61 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Methylated-DNA--protein-cysteine methyltransferase |
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Name: | Methylated-DNA--protein-cysteine methyltransferase |
Synonyms: | 6-O-methylguanine-DNA methyltransferase | MGMT | MGMT_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 21651.27 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_144711 |
Residue: | 207 |
Sequence: | MDKDCEMKRTTLDSPLGKLELSGCEQGLHEIKLLGKGTSAADAVEVPAPAAVLGGPEPLM
QCTAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYQQLAAL
AGNPKAARAVGGAMRGNPVPILIPCHRVVCSSGAVGNYSGGLAVKEWLLAHEGHRLGKPG
LGGSSGLAGAWLKGAGATSGSPPAGRN
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BDBM50106511 |
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n/a |
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Name | BDBM50106511 |
Synonyms: | 2-{8-[2-Amino-6-(4-bromo-thiophen-2-ylmethoxy)-purin-9-yl]-octyloxy}-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol | CHEMBL336947 |
Type | Small organic molecule |
Emp. Form. | C24H34BrN5O7S |
Mol. Mass. | 616.525 |
SMILES | Nc1nc(OCc2cc(Br)cs2)c2ncn(CCCCCCCCO[C@H]3OC(CO)[C@@H](O)[C@@H](O)C3O)c2n1 |
Structure |
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