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TargetMethylated-DNA--protein-cysteine methyltransferase
LigandBDBM50106511
Substrate/Competitorn/a
Meas. Tech.ChEMBL_103719 (CHEMBL712287)
IC50 32±n/a nM
Citation Reinhard, JHull, WEvon der Lieth, CWEichhorn, UKliem, HCKaina, BWiessler, M Monosaccharide-linked inhibitors of O(6)-methylguanine-DNA methyltransferase (MGMT): synthesis, molecular modeling, and structure-activity relationships. J Med Chem44:4050-61 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Methylated-DNA--protein-cysteine methyltransferase
Name:Methylated-DNA--protein-cysteine methyltransferase
Synonyms:6-O-methylguanine-DNA methyltransferase | MGMT | MGMT_HUMAN
Type:PROTEIN
Mol. Mass.:21651.27
Organism:Homo sapiens (Human)
Description:ChEMBL_144711
Residue:207
Sequence:
MDKDCEMKRTTLDSPLGKLELSGCEQGLHEIKLLGKGTSAADAVEVPAPAAVLGGPEPLM
QCTAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYQQLAAL
AGNPKAARAVGGAMRGNPVPILIPCHRVVCSSGAVGNYSGGLAVKEWLLAHEGHRLGKPG
LGGSSGLAGAWLKGAGATSGSPPAGRN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50106511
n/a
NameBDBM50106511
Synonyms:2-{8-[2-Amino-6-(4-bromo-thiophen-2-ylmethoxy)-purin-9-yl]-octyloxy}-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol | CHEMBL336947
TypeSmall organic molecule
Emp. Form.C24H34BrN5O7S
Mol. Mass.616.525
SMILESNc1nc(OCc2cc(Br)cs2)c2ncn(CCCCCCCCO[C@H]3OC(CO)[C@@H](O)[C@@H](O)C3O)c2n1
Structure
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