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TargetBeta-3 adrenergic receptor
LigandBDBM50106833
Substrate/Competitorn/a
Meas. Tech.ChEBML_39053
Ki 9±n/a nM
Citation Gavai AVSher PMMikkilineni ABPoss KMMcCann PJGirotra RNFisher LGWu GBednarz MSMathur AWang TCSun CQSlusarchyk DASkwish SAllen GTHillyer DEFrohlich BHAbboa-Offei BECap MWaldron TLGeorge RJTesfamariam BHarper TWCiosek CPYoung DADickinson KESeymour AAArbeeny CMWashburn WN BMS-196085: a potent and selective full agonist of the human beta(3) adrenergic receptor. Bioorg Med Chem Lett 11:3041-4 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Beta-3 adrenergic receptor
Name:Beta-2 adrenergic receptor and beta-3 adrenergic receptor
Synonyms:ADRB3 | B3AR | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:43534.88
Organism:Homo sapiens (Human)
Description:n/a
Residue:408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50106833
n/a
NameBDBM50106833
Synonyms:CHEMBL317648 | N-(5-{(R)-2-[(R)-1-(4-Difluoromethoxy-phenyl)-1-methyl-2-phenyl-ethylamino]-1-hydroxy-ethyl}-2-hydroxy-phenyl)-methanesulfonamide
TypeSmall organic molecule
Emp. Form.C25H28F2N2O5S
Mol. Mass.506.562
SMILESC[C@](Cc1ccccc1)(NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1)c1ccc(OC(F)F)cc1
Structure
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