| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-K receptor |
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| Ligand | BDBM50106891 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_209021 |
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| IC50 | 5.5±n/a nM |
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| Citation |  Gerspacher, M; La Vecchia, L; Mah, R; von Sprecher, A; Anderson, GP; Subramanian, N; Hauser, K; Bammerlin, H; Kimmel, S; Pawelzik, V; Ryffel, K; Ball, HA Dual neurokinin NK(1)/NK(2) antagonists: N-[(R,R)-(E)-1-arylmethyl-3-(2-oxo-azepan-3-yl)carbamoyl]allyl-N-methyl-3,5-bis(trifluoromethyl)benzamides and 3-[N'-3,5-bis(trifluoromethyl)benzoyl-N-arylmethyl-N'-methylhydrazino]-N-[(R)-2-oxo-azepan-3-yl]propionamides. Bioorg Med Chem Lett11:3081-4 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-K receptor |
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| Name: | Substance-K receptor |
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| Synonyms: | NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3 |
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| Type: | Protein |
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| Mol. Mass.: | 44455.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21452 |
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| Residue: | 398 |
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| Sequence: | MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILA
HRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATK
CVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLR
HLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSST
MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMA
GDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
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| BDBM50106891 |
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| n/a |
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| Name | BDBM50106891 |
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| Synonyms: | 3-[N'-(3,5-Bis-trifluoromethyl-benzoyl)-N-(3,4-dichloro-benzyl)-N'-methyl-hydrazino]-N-((R)-2-oxo-azepan-3-yl)-propionamide | CHEMBL318606 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26Cl2F6N4O3 |
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| Mol. Mass. | 627.406 |
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| SMILES | CN(N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1)C(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F |
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| Structure | 
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