| Reaction Details |
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 | Report a problem with these data |
| Target | Platelet-activating factor acetylhydrolase |
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| Ligand | BDBM50107513 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_101009 |
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| IC50 | 1.6±n/a nM |
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| Citation |  Boyd, HF; Fell, SC; Hickey, DM; Ife, RJ; Leach, CA; Macphee, CH; Milliner, KJ; Pinto, IL; Rawlings, DA; Smith, SA; Stansfield, IG; Stanway, SJ; Theobald, CJ; Whittaker, CM Potent, orally active inhibitors of lipoprotein-associated phospholipase A(2): 1-(biphenylmethylamidoalkyl)-pyrimidones. Bioorg Med Chem Lett12:51-5 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Platelet-activating factor acetylhydrolase |
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| Name: | Platelet-activating factor acetylhydrolase |
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| Synonyms: | 1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | LDL-PLA(2) | LDL-associated phospholipase A2 | PAF 2-acylhydrolase | PAF acetylhydrolase | PAFAH | PAFA_HUMAN | PLA2G7 | Platelet-activating factor acetylhydrolase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50084.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_156212 |
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| Residue: | 441 |
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| Sequence: | MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGN
GPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNI
LRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHR
DRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDID
HGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMF
PLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFA
TGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGT
NINTTNQHIMLQNSSGIEKYN
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| BDBM50107513 |
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| n/a |
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| Name | BDBM50107513 |
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| Synonyms: | CHEMBL153579 | N-(2'-Chloro-biphenyl-4-ylmethyl)-2-[2-(4-fluoro-benzylsulfanyl)-5-(1-methyl-1H-pyrazol-4-ylmethyl)-4-oxo-4H-pyrimidin-1-yl]-N-methyl-acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C32H29ClFN5O2S |
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| Mol. Mass. | 602.121 |
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| SMILES | CN(Cc1ccc(cc1)-c1ccccc1Cl)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 |
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| Structure | 
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