| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Endothelin-1 receptor |
|---|
| Ligand | BDBM50104992 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_65801 (CHEMBL877703) |
|---|
| IC50 | 0.051000±n/a nM |
|---|
| Citation |  Morimoto, H; Shimadzu, H; Hosaka, T; Kawase, Y; Yasuda, K; Kikkawa, K; Yamauchi-Kohno, R; Yamada, K Modifications and structure-activity relationships at the 2-position of 4-sulfonamidopyrimidine derivatives as potent endothelin antagonists. Bioorg Med Chem Lett12:81-4 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Endothelin-1 receptor |
|---|
| Name: | Endothelin-1 receptor |
|---|
| Synonyms: | EDNRA | EDNRA_PIG | Endothelin receptor ET-A |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 48707.29 |
|---|
| Organism: | Sus scrofa |
|---|
| Description: | ChEMBL_65803 |
|---|
| Residue: | 427 |
|---|
| Sequence: | METFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERS
SHKDSIN
|
|
|
|---|
| BDBM50104992 |
|---|
| n/a |
|---|
| Name | BDBM50104992 |
|---|
| Synonyms: | CHEMBL114700 | N-[6-[2-(5-Bromo-pyrimidin-2-yloxy)-ethoxy]-5-(3-methoxy-phenoxy)-pyrimidin-4-yl]-4-tert-butyl-benzenesulfonamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H28BrN5O6S |
|---|
| Mol. Mass. | 630.51 |
|---|
| SMILES | COc1cccc(Oc2c(NS(=O)(=O)c3ccc(cc3)C(C)(C)C)ncnc2OCCOc2ncc(Br)cn2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
