Reaction Details |
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Target | Endothelin-1 receptor |
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Ligand | BDBM50107558 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_65801 |
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IC50 | 0.150000±n/a nM |
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Citation | Morimoto, H; Shimadzu, H; Hosaka, T; Kawase, Y; Yasuda, K; Kikkawa, K; Yamauchi-Kohno, R; Yamada, K Modifications and structure-activity relationships at the 2-position of 4-sulfonamidopyrimidine derivatives as potent endothelin antagonists. Bioorg Med Chem Lett12:81-4 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Endothelin-1 receptor |
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Name: | Endothelin-1 receptor |
Synonyms: | EDNRA | EDNRA_PIG | Endothelin receptor ET-A |
Type: | PROTEIN |
Mol. Mass.: | 48707.29 |
Organism: | Sus scrofa |
Description: | ChEMBL_65803 |
Residue: | 427 |
Sequence: | METFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERS
SHKDSIN
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BDBM50107558 |
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n/a |
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Name | BDBM50107558 |
Synonyms: | CHEMBL167314 | N-[6-[2-(5-Bromo-pyrimidin-2-yloxy)-ethoxy]-2-(2-hydroxy-ethylsulfanyl)-5-(2-methoxy-phenoxy)-pyrimidin-4-yl]-4-tert-butyl-benzenesulfonamide |
Type | Small organic molecule |
Emp. Form. | C29H32BrN5O7S2 |
Mol. Mass. | 706.628 |
SMILES | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)nc(SCCO)nc1OCCOc1ncc(Br)cn1 |
Structure |
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