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TargetDelta-type opioid receptor
LigandBDBM50108447
Substrate/Competitorn/a
Meas. Tech.ChEBML_145327
IC50 4350±n/a nM
Citation Semple, GAndersson, BMChhajlani, VGeorgsson, JJohansson, MLindschoten, MPontén, FRosenquist, ASörensen, HSwanson, LSwanson, M 3-Aryl pyridone derivatives. Potent and selective kappa opioid receptor agonists. Bioorg Med Chem Lett12:197-200 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Delta-type opioid receptor
Name:Delta-type opioid receptor
Synonyms:D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:40382.98
Organism:Homo sapiens (Human)
Description:Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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  Blast E-value cutoff:
BDBM50108447
n/a
NameBDBM50108447
Synonyms:3-(5-Fluoro-2-methoxy-phenyl)-1-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-1H-pyridin-2-one | CHEMBL64284
TypeSmall organic molecule
Emp. Form.C24H25FN2O2
Mol. Mass.392.4659
SMILESCOc1ccc(F)cc1-c1cccn(C(CN2CCCC2)c2ccccc2)c1=O
Structure
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