Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50108447 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_145327 |
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IC50 | 4350±n/a nM |
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Citation | Semple, G; Andersson, BM; Chhajlani, V; Georgsson, J; Johansson, M; Lindschoten, M; Pontén, F; Rosenquist, A; Sörensen, H; Swanson, L; Swanson, M 3-Aryl pyridone derivatives. Potent and selective kappa opioid receptor agonists. Bioorg Med Chem Lett12:197-200 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50108447 |
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n/a |
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Name | BDBM50108447 |
Synonyms: | 3-(5-Fluoro-2-methoxy-phenyl)-1-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-1H-pyridin-2-one | CHEMBL64284 |
Type | Small organic molecule |
Emp. Form. | C24H25FN2O2 |
Mol. Mass. | 392.4659 |
SMILES | COc1ccc(F)cc1-c1cccn(C(CN2CCCC2)c2ccccc2)c1=O |
Structure |
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