Reaction Details |
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Target | Cruzipain |
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Ligand | BDBM50108866 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_51847 (CHEMBL664070) |
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Ki | 5±n/a nM |
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Citation | Huang, L; Lee, A; Ellman, JA Identification of potent and selective mechanism-based inhibitors of the cysteine protease cruzain using solid-phase parallel synthesis. J Med Chem45:676-84 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Cruzipain |
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Name: | Cruzipain |
Synonyms: | CYSP_TRYCR | Cruzain | Cruzaine | Major cysteine proteinase |
Type: | Protein |
Mol. Mass.: | 49831.41 |
Organism: | Trypanosoma cruzi |
Description: | P25779 |
Residue: | 467 |
Sequence: | MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLS
VFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEV
VGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDK
TDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVEL
PQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYW
IIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSY
FVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVR
SSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL
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BDBM50108866 |
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n/a |
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Name | BDBM50108866 |
Synonyms: | (1-{1-Benzyl-3-[1-(2,2-dimethyl-propyl)-1,3,3-trimethyl-butylsulfanyl]-2-oxo-propylcarbamoyl}-2-phenyl-ethyl)-carbamic acid benzyl ester | CHEMBL161573 | benzyl (S)-1-oxo-1-((S)-3-oxo-4-(2,2,4,6,6-pentamethylheptan-4-ylthio)-1-phenylbutan-2-ylamino)-3-phenylpropan-2-ylcarbamate |
Type | Small organic molecule |
Emp. Form. | C39H52N2O4S |
Mol. Mass. | 644.906 |
SMILES | CC(C)(C)CC(C)(CC(C)(C)C)SCC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 |
Structure |
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