| Reaction Details |
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 | Report a problem with these data |
| Target | RAS guanyl-releasing protein 1 |
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| Ligand | BDBM50057514 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_163499 (CHEMBL772411) |
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| Ki | 0.85±n/a nM |
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| Citation |  Rong, SB; Enyedy, IJ; Qiao, L; Zhao, L; Ma, D; Pearce, LL; Lorenzo, PS; Stone, JC; Blumberg, PM; Wang, S; Kozikowski, AP Structural basis of RasGRP binding to high-affinity PKC ligands. J Med Chem45:853-60 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| RAS guanyl-releasing protein 1 |
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| Name: | RAS guanyl-releasing protein 1 |
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| Synonyms: | GRP1_RAT | RAS guanyl releasing protein 1 | Rasgrp | Rasgrp1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 90263.87 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_163499 |
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| Residue: | 795 |
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| Sequence: | MGTLGKAREAPRKPCHGSRAGPKGRLEAKSTNSPLPAQPSLAQITQFRMMVSLGHLAKGA
SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIIISSAELLQKLMNLYKDALEKNSPG
ICLKICYFVRYWITEFWIMFKMDASLTSTMEEFQDLVKANGEESHCHLIDTTQINSRDWS
RKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKE
NPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIHVAQKLHQLQNFNTLMAVIGG
LCHSSISRLKETSSHVPHEINKVLGEMTELLSSCRNYDNYRRAYGECTHFKIPILGVHLK
DLISLYEAMPDYLEDGKVNVQKLLALYNHINELVQLQDVAPPLDANKDLVHLLTLSLDLY
YTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFK
NYDLDQDGYISQEEFEKIAASFPFSFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGF
PHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRSKSPAV
STENISSVVPMSTLCPLGTKDLLHAPEEGSFIFQNGEVVDHSEESKDRTIMLLGVSSQKI
SVRLKRTVAHKTTQTESFPWVGGEMPPGHFVLTSPRKSAQGALYVHSPASPCPSPALVRK
RAFVKWENKESLIKPKPELHLRLRTYQELEQEVNTLRADNDALKIQLKYAQKQIESLQLG
KSNHVLAQMDHGDGT
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| BDBM50057514 |
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| n/a |
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| Name | BDBM50057514 |
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| Synonyms: | (10S,13S)-13-Hydroxymethyl-10-isopropyl-9-methyl-5-octyl-3,9,12-triaza-tricyclo[6.6.1.0*4,15*]pentadeca-1,4,6,8(15)-tetraen-11-one | 13-Hydroxymethyl-10-isopropyl-9-methyl-5-octyl-3,9,12-triaza-tricyclo[6.6.1.0*4,15*]pentadeca-1,4,6,8(15)-tetraen-11-one (n-octyl-ILV) | CHEMBL285801 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H39N3O2 |
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| Mol. Mass. | 413.5961 |
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| SMILES | CCCCCCCCc1ccc2N(C)[C@@H](C(C)C)C(=O)N[C@H](CO)Cc3c[nH]c1c23 |
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| Structure | 
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