| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Isoform 1 of Calcitonin receptor (1) |
|---|
| Ligand | BDBM50110271 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_42610 (CHEMBL654175) |
|---|
| Ki | 43±n/a nM |
|---|
| Citation |  Taylor, JW; Jin, QK; Sbacchi, M; Wang, L; Belfiore, P; Garnier, M; Kazantzis, A; Kapurniotu, A; Zaratin, PF; Scheideler, MA Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept for potent calcitonin analogues. J Med Chem45:1108-21 (2002) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Isoform 1 of Calcitonin receptor (1) |
|---|
| Name: | Isoform 1 of Calcitonin receptor (1) |
|---|
| Synonyms: | CALCR | CALCR_HUMAN | CT-R | Calcitonin receptor | Calcitonin receptor (1) |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 55343.05 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_42610 |
|---|
| Residue: | 474 |
|---|
| Sequence: | MRFTFTSRCLALFLLLNHPTPILPAFSNQTYPTIEPKPFLYVVGRKKMMDAQYKCYDRMQ
QLPAYQGEGPYCNRTWDGWLCWDDTPAGVLSYQFCPDYFPDFDPSEKVTKYCDEKGVWFK
HPENNRTWSNYTMCNAFTPEKLKNAYVLYYLAIVGHSLSIFTLVISLGIFVFFRSLGCQR
VTLHKNMFLTYILNSMIIIIHLVEVVPNGELVRRDPVSCKILHFFHQYMMACNYFWMLCE
GIYLHTLIVVAVFTEKQRLRWYYLLGWGFPLVPTTIHAITRAVYFNDNCWLSVETHLLYI
IHGPVMAALVVNFFFLLNIVRVLVTKMRETHEAESHMYLKAVKATMILVPLLGIQFVVFP
WRPSNKMLGKIYDYVMHSLIHFQGFFVATIYCFCNNEVQTTVKRQWAQFKIQWNQRWGRR
PSNRSARAAAAAAEAGDIPIYICHQEPRNEPANNQGEESAEIIPLNIIEQESSA
|
|
|
|---|
| BDBM50110271 |
|---|
| n/a |
|---|
| Name | BDBM50110271 |
|---|
| Synonyms: | CGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAP-amide | CHEMBL2369892 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C150H227N39O44S3 |
|---|
| Mol. Mass. | 3376.837 |
|---|
| SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](N)CS)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@@H]1C(N)=O |
|---|
| Structure | 
|
|---|
Search and Browse
