| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine N-methyltransferase |
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| Ligand | BDBM50110311 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_87238 (CHEMBL696458) |
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| IC50 | 120±n/a nM |
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| Citation |  Apelt, J; Ligneau, X; Pertz, HH; Arrang, JM; Ganellin, CR; Schwartz, JC; Schunack, W; Stark, H Development of a new class of nonimidazole histamine H(3) receptor ligands with combined inhibitory histamine N-methyltransferase activity. J Med Chem45:1128-41 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine N-methyltransferase |
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| Name: | Histamine N-methyltransferase |
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| Synonyms: | HNMT_RAT | Hnmt |
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| Type: | PROTEIN |
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| Mol. Mass.: | 33931.03 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_87236 |
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| Residue: | 295 |
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| Sequence: | MASFMRSLFSDHSRYVESFRRFLNNSTEHQCMQEFMDKKLPGIIARIGETKAEIKILSIG
GGAGEIDLQILSKVQAQYPGICINNEVVEPNAEQIVKYKELVAKTSNMENIKFAWHKETS
SEYQKRVVEEDEEPPKWDFIHMIQMLYYVKDIPATLKFFHGLLAANAKILIILVSGTSGW
EKLWKKYGFRLPRDDLCQYVTSSDLAQILDDLGIKYECYDLLSTMDITDCFIDGNENGDL
LWDFLTETCNFIKTAPLDLKEEIMKDLQEPEFSVKKEGKVLFNNNLSFIVVEANV
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| BDBM50110311 |
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| n/a |
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| Name | BDBM50110311 |
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| Synonyms: | CHEMBL276938 | {2-[4-(3-Piperidin-1-yl-propoxy)-phenyl]-ethyl}-quinolin-4-yl-amine; Oxalic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C25H31N3O |
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| Mol. Mass. | 389.5331 |
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| SMILES | C(COc1ccc(CCNc2ccnc3ccccc23)cc1)CN1CCCCC1 |
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| Structure | 
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