| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M2 |
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| Ligand | BDBM50110524 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_139772 |
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| Ki | 0.300000±n/a nM |
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| Citation |  Kozlowski, JA; Zhou, G; Tagat, JR; Lin, SI; McCombie, SW; Ruperto, VB; Duffy, RA; McQuade, RA; Crosby, G; Taylor, LA; Billard, W; Binch, H; Lachowicz, JE Substituted 2-(R)-methyl piperazines as muscarinic M(2) selective ligands. Bioorg Med Chem Lett12:791-4 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M2 |
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| Name: | Muscarinic acetylcholine receptor M2 |
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| Synonyms: | ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2 |
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| Type: | GPCR |
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| Mol. Mass.: | 51730.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08172 |
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| Residue: | 466 |
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| Sequence: | MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
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| BDBM50110524 |
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| n/a |
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| Name | BDBM50110524 |
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| Synonyms: | 4-Cyclohexyl-1-[4-(4-methoxy-benzenesulfonyl)-benzyl]-2-methyl-piperazine | CHEMBL165439 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H34N2O3S |
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| Mol. Mass. | 442.614 |
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| SMILES | COc1ccc(cc1)S(=O)(=O)c1ccc(CN2CCN(C[C@H]2C)C2CCCCC2)cc1 |
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| Structure | 
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