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TargetHuman immunodeficiency virus type 1 reverse transcriptase
LigandBDBM50110799
Substrate/Competitorn/a
Meas. Tech.ChEMBL_195083
IC50 15000±n/a nM
Citation Khandazhinskaya ALShirokova EASkoblov YSVictorova LSGoryunova LYBeabealashvilli RSPronyaeva TRFedyuk NVZolin VVPokrovsky AGKukhanova MK Carbocyclic dinucleoside polyphosphonates: interaction with HIV reverse transcriptase and antiviral activity. J Med Chem 45:1284-91 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Human immunodeficiency virus type 1 reverse transcriptase
Name:Human immunodeficiency virus type 1 reverse transcriptase
Synonyms:Reverse transcriptase/RNaseH
Type:PROTEIN
Mol. Mass.:65229.15
Organism:Human immunodeficiency virus 1
Description:ChEMBL_1473730
Residue:566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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  Blast E-value cutoff:
BDBM50110799
n/a
NameBDBM50110799
Synonyms:CHEMBL280273 | P,P'-Bis {[4-(guanine-9-yl)cyclopent-2-enyl]oxy-methylphosphonyl}difluorodiphosphonate
TypeSmall organic molecule
Emp. Form.C23H28F2N10O14P4
Mol. Mass.830.4189
SMILESNc1nc2n(cnc2c(=O)[nH]1)C1CC(OCP(O)(=O)OP(O)(=O)C(F)(F)P(O)(=O)OP(O)(=O)COC2CC(C=C2)n2cnc3c2nc(N)[nH]c3=O)C=C1 |c:40,56|
Structure
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