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TargetReverse transcriptase/RNaseH
LigandBDBM50110793
Substrate/Competitorn/a
Meas. Tech.ChEMBL_195083 (CHEMBL797537)
IC50 25000±n/a nM
Citation Khandazhinskaya, ALShirokova, EASkoblov, YSVictorova, LSGoryunova, LYBeabealashvilli, RSPronyaeva, TRFedyuk, NVZolin, VVPokrovsky, AGKukhanova, MK Carbocyclic dinucleoside polyphosphonates: interaction with HIV reverse transcriptase and antiviral activity. J Med Chem45:1284-91 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Reverse transcriptase/RNaseH
Name:Reverse transcriptase/RNaseH
Synonyms:HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:PROTEIN
Mol. Mass.:65229.15
Organism:Human immunodeficiency virus 1
Description:ChEMBL_1473730
Residue:566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50110793
n/a
NameBDBM50110793
Synonyms:9-[4-(Difluoromethyldiphosphonyl)oxyphosphonylmethoxy)-cyclopent-2-enyl]guanine | CHEMBL24118
TypeSmall organic molecule
Emp. Form.C12H16F2N5O10P3
Mol. Mass.521.201
SMILESNc1nc2n(cnc2c(=O)[nH]1)C1CC(OCP(O)(=O)OP(O)(=O)C(F)(F)P(O)(O)=O)C=C1 |c:32|
Structure
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