Reaction Details |
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Target | Cytosolic phospholipase A2 beta |
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Ligand | BDBM50110879 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_156210 (CHEMBL767152) |
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IC50 | 48±n/a nM |
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Citation | Connolly, S; Bennion, C; Botterell, S; Croshaw, PJ; Hallam, C; Hardy, K; Hartopp, P; Jackson, CG; King, SJ; Lawrence, L; Mete, A; Murray, D; Robinson, DH; Smith, GM; Stein, L; Walters, I; Wells, E; Withnall, WJ Design and synthesis of a novel and potent series of inhibitors of cytosolic phospholipase A(2) based on a 1,3-disubstituted propan-2-one skeleton. J Med Chem45:1348-62 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Cytosolic phospholipase A2 beta |
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Name: | Cytosolic phospholipase A2 beta |
Synonyms: | Cytosolic phospholipase A2 beta | PA24B_HUMAN | PLA2G4B | Phospholipase A2 group 1VB | Phospholipase A2 group IVB | cPLA2-beta |
Type: | PROTEIN |
Mol. Mass.: | 87967.69 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_156210 |
Residue: | 781 |
Sequence: | MAVAEVSRTCLLTVRVLQAHRLPSKDLVTPSDCYVTLWLPTACSHRLQTRTVKNSSSPVW
NQSFHFRIHRQLKNVMELKVFDQDLVTGDDPVLSVLFDAGTLRAGEFRRESFSLSPQGEG
RLEVEFRLQSLADRGEWLVSNGVLVARELSCLHVQLEETGDQKSSEHRVQLVVPGSCEGP
QEASVGTGTFRFHCPACWEQELSIRLQDAPEEQLKAPLSALPSGQVVRLVFPTSQEPLMR
VELKKEAGLRELAVRLGFGPCAEEQAFLSRRKQVVAAALRQALQLDGDLQEDEIPVVAIM
ATGGGIRAMTSLYGQLAGLKELGLLDCVSYITGASGSTWALANLYEDPEWSQKDLAGPTE
LLKTQVTKNKLGVLAPSQLQRYRQELAERARLGYPSCFTNLWALINEALLHDEPHDHKLS
DQREALSHGQNPLPIYCALNTKGQSLTTFEFGEWCEFSPYEVGFPKYGAFIPSELFGSEF
FMGQLMKRLPESRICFLEGIWSNLYAANLQDSLYWASEPSQFWDRWVRNQANLDKEQVPL
LKIEEPPSTAGRIAEFFTDLLTWRPLAQATHNFLRGLHFHKDYFQHPHFSTWKATTLDGL
PNQLTPSEPHLCLLDVGYLINTSCLPLLQPTRDVDLILSLDYNLHGAFQQLQLLGRFCQE
QGIPFPPISPSPEEQLQPRECHTFSDPTCPGAPAVLHFPLVSDSFREYSAPGVRRTPEEA
AAGEVNLSSSDSPYHYTKVTYSQEDVDKLLHLTHYNVCNNQEQLLEALRQAVQRRRQRRP
H
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BDBM50110879 |
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n/a |
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Name | BDBM50110879 |
Synonyms: | 4-{2-Oxo-3-[4-(5-phenyl-pentyloxy)-phenoxy]-propoxy}-benzoic acid | CHEMBL30130 |
Type | Small organic molecule |
Emp. Form. | C27H28O6 |
Mol. Mass. | 448.5076 |
SMILES | OC(=O)c1ccc(OCC(=O)COc2ccc(OCCCCCc3ccccc3)cc2)cc1 |
Structure |
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