| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor gamma/Retinoic acid receptor RXR-alpha |
|---|
| Ligand | BDBM50111008 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_153614 (CHEMBL759726) |
|---|
| EC50 | 813.0±n/a nM |
|---|
| Citation |  Momose, Y; Maekawa, T; Yamano, T; Kawada, M; Odaka, H; Ikeda, H; Sohda, T Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as insulin sensitizers with antidiabetic activities. J Med Chem45:1518-34 (2002) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Peroxisome proliferator-activated receptor gamma/Retinoic acid receptor RXR-alpha |
|---|
| Name: | Peroxisome proliferator-activated receptor gamma/Retinoic acid receptor RXR-alpha |
|---|
| Synonyms: | Peroxisome Proliferator-Activated Receptor gamma/Retinoid X receptor alpha | RXR alpha/PPAR gamma |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of EBI is 43803 |
|---|
| Components: | This complex has 3 components. |
|---|
| Component 1 |
| Name: | Peroxisome proliferator-activated receptor gamma |
|---|
| Synonyms: | NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2 |
|---|
| Type: | Nuclear Receptor |
|---|
| Mol. Mass.: | 57613.46 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P37231 |
|---|
| Residue: | 505 |
|---|
| Sequence: | MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL
LQVIKKTETDMSLHPLLQEIYKDLY
|
|
|
|---|
| Component 2 |
| Name: | Retinoic acid receptor RXR-alpha |
|---|
| Synonyms: | NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 50820.38 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1456363 |
|---|
| Residue: | 462 |
|---|
| Sequence: | MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
|
|
|
|---|
| BDBM50111008 |
|---|
| n/a |
|---|
| Name | BDBM50111008 |
|---|
| Synonyms: | 5-{3-[4-(5-Methyl-2-phenyl-thiazol-4-ylmethoxy)-phenyl]-propyl}-oxazolidine-2,4-dione | CHEMBL37950 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H22N2O4S |
|---|
| Mol. Mass. | 422.497 |
|---|
| SMILES | Cc1sc(nc1COc1ccc(CCCc2oc(=O)[nH]c2O)cc1)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
