Reaction Details |
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Target | Plasminogen activator inhibitor 1 |
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Ligand | BDBM50111316 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_222792 (CHEMBL847120) |
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IC50 | 510±n/a nM |
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Citation | Folkes, A; Brown, SD; Canne, LE; Chan, J; Engelhardt, E; Epshteyn, S; Faint, R; Golec, J; Hanel, A; Kearney, P; Leahy, JW; Mac, M; Matthews, D; Prisbylla, MP; Sanderson, J; Simon, RJ; Tesfai, Z; Vicker, N; Wang, S; Webb, RR; Charlton, P Design, synthesis and in vitro evaluation of potent, novel, small molecule inhibitors of plasminogen activator inhibitor-1. Bioorg Med Chem Lett12:1063-6 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Plasminogen activator inhibitor 1 |
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Name: | Plasminogen activator inhibitor 1 |
Synonyms: | Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1 | PAI1_HUMAN | PLANH1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator inhibitor-1 | Plasminogen activator-1 (PAI-1) | SERPINE1 |
Type: | Enzyme |
Mol. Mass.: | 45064.00 |
Organism: | Homo sapiens (Human) |
Description: | P05121 |
Residue: | 402 |
Sequence: | MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
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BDBM50111316 |
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n/a |
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Name | BDBM50111316 |
Synonyms: | 8-[4-(3,6-Dioxo-5-{4-[(thiophene-2-carbonyl)-amino]-benzylidene}-piperazin-2-ylidenemethyl)-phenoxy]-octanoic acid | CHEMBL10062 |
Type | Small organic molecule |
Emp. Form. | C31H31N3O6S |
Mol. Mass. | 573.659 |
SMILES | OC(=O)CCCCCCCOc1ccc(\C=c2\[nH]c(=O)\c(=C\c3ccc(NC(=O)c4cccs4)cc3)[nH]c2=O)cc1 |
Structure |
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