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TargetPlasminogen activator inhibitor 1
LigandBDBM50111309
Substrate/Competitorn/a
Meas. Tech.ChEMBL_222791 (CHEMBL847119)
IC50 510±n/a nM
Citation Folkes, ABrown, SDCanne, LEChan, JEngelhardt, EEpshteyn, SFaint, RGolec, JHanel, AKearney, PLeahy, JWMac, MMatthews, DPrisbylla, MPSanderson, JSimon, RJTesfai, ZVicker, NWang, SWebb, RRCharlton, P Design, synthesis and in vitro evaluation of potent, novel, small molecule inhibitors of plasminogen activator inhibitor-1. Bioorg Med Chem Lett12:1063-6 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Plasminogen activator inhibitor 1
Name:Plasminogen activator inhibitor 1
Synonyms:Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1 | PAI1_HUMAN | PLANH1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator inhibitor-1 | Plasminogen activator-1 (PAI-1) | SERPINE1
Type:Enzyme
Mol. Mass.:45064.00
Organism:Homo sapiens (Human)
Description:P05121
Residue:402
Sequence:
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50111309
n/a
NameBDBM50111309
Synonyms:8-{4-[(6-Benzo[b]thiophen-3-yl-4-hydroxy-2-oxo-1,2-dihydro-quinoline-3-carbonyl)-amino]-phenoxy}-octanoic acid | CHEMBL10240
TypeSmall organic molecule
Emp. Form.C32H30N2O6S
Mol. Mass.570.655
SMILESOC(=O)CCCCCCCOc1ccc(NC(=O)c2c(O)c3cc(ccc3[nH]c2=O)-c2csc3ccccc23)cc1
Structure
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