| Reaction Details |
|---|
 | Report a problem with these data |
| Target | DNA polymerase I, thermostable |
|---|
| Ligand | BDBM50111320 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_209735 |
|---|
| IC50 | 900±n/a nM |
|---|
| Citation |  Alberti, P; Schmitt, P; Nguyen, CH; Rivalle, C; Hoarau, M; Grierson, DS; Mergny, JL Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase. Bioorg Med Chem Lett12:1071-4 (2002) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| DNA polymerase I, thermostable |
|---|
| Name: | DNA polymerase I, thermostable |
|---|
| Synonyms: | DNA polymerase I, thermostable | DPO1_THEAQ | Taq polymerase 1 | pol1 | polA |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 93906.95 |
|---|
| Organism: | Thermus aquaticus |
|---|
| Description: | ChEMBL_1289218 |
|---|
| Residue: | 832 |
|---|
| Sequence: | MRGMLPLFEPKGRVLLVDGHHLAYRTFHALKGLTTSRGEPVQAVYGFAKSLLKALKEDGD
AVIVVFDAKAPSFRHEAYGGYKAGRAPTPEDFPRQLALIKELVDLLGLARLEVPGYEADD
VLASLAKKAEKEGYEVRILTADKDLYQLLSDRIHVLHPEGYLITPAWLWEKYGLRPDQWA
DYRALTGDESDNLPGVKGIGEKTARKLLEEWGSLEALLKNLDRLKPAIREKILAHMDDLK
LSWDLAKVRTDLPLEVDFAKRREPDRERLRAFLERLEFGSLLHEFGLLESPKALEEAPWP
PPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRDLKEARGLLAKDLSVLA
LREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRYGGEWTEEAGERAALSERLFANLWGRL
EGEERLLWLYREVERPLSAVLAHMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGH
PFNLNSRDQLERVLFDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKILQYRELTK
LKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQRIRRAFIA
EEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVDPLMRR
AAKTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQSFPKVRAWIEKTLEEGRRRGYV
ETLFGRRRYVPDLEARVKSVREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARML
LQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKE
|
|
|
|---|
| BDBM50111320 |
|---|
| n/a |
|---|
| Name | BDBM50111320 |
|---|
| Synonyms: | CHEMBL274096 | N'-(10-Methoxy-13H-5,13-diaza-dibenzo[a,i]fluoren-6-yl)-N,N-dimethyl-propane-1,3-diamine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H26N4O |
|---|
| Mol. Mass. | 398.5001 |
|---|
| SMILES | COc1ccc2c3[nH]c4c(c(NCCCN(C)C)nc5ccccc45)c3ccc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
