| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50068808 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_54285 (CHEMBL666804) |
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| Ki | 0.000014±n/a nM |
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| Citation |  Vaidya, CM; Wright, JE; Rosowsky, A Synthesis and in vitro antitumor activity of new deaza analogues of the nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine (PT523). J Med Chem45:1690-6 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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|
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| BDBM50068808 |
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| n/a |
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| Name | BDBM50068808 |
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| Synonyms: | CHEMBL297088 | N-(4-Carboxy-4-{4-[(2,4-diamino-quinazolin-6-ylmethyl)-amino]-benzoylamino}-butyl)-phthalamic acid | N-(4-Carboxy-4-{4-[1-(6,8-diamino-quinoxalin-2-ylmethyl)-but-3-ynyl]-benzoylamino}-butyl)-phthalamic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C29H29N7O6 |
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| Mol. Mass. | 571.5839 |
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| SMILES | Nc1nc(N)c2cc(CNc3ccc(cc3)C(=O)NC(CCCNC(=O)c3ccccc3C(O)=O)C(O)=O)ccc2n1 |
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| Structure | 
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