Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50111550 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_54285 (CHEMBL666804) |
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Ki | 0.00033±n/a nM |
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Citation | Vaidya, CM; Wright, JE; Rosowsky, A Synthesis and in vitro antitumor activity of new deaza analogues of the nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine (PT523). J Med Chem45:1690-6 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21453.99 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human DHFR. |
Residue: | 187 |
Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50111550 |
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n/a |
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Name | BDBM50111550 |
Synonyms: | CHEMBL296545 | N-(4-Carboxy-4-{4-[(6,8-diamino-quinoxalin-2-ylmethyl)-amino]-benzoylamino}-butyl)-phthalamic acid |
Type | Small organic molecule |
Emp. Form. | C29H29N7O6 |
Mol. Mass. | 571.5839 |
SMILES | Nc1cc(N)c2nc(CNc3ccc(cc3)C(=O)NC(CCCNC(=O)c3ccccc3C(O)=O)C(O)=O)cnc2c1 |
Structure |
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