| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H1 receptor |
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| Ligand | BDBM50111634 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_84709 |
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| Ki | 40±n/a nM |
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| Citation |  Mouithys-Mickalad, A; Poupaert, JH; Spampinato, S; Lesieur, D Synthesis and pharmacological evaluation of 6-piperidino- and 6-piperazinoalkyl-2(3H)-benzothiazolones as mixed sigma/5-HT(1A) ligands. Bioorg Med Chem Lett12:1149-52 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H1 receptor |
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| Name: | Histamine H1 receptor |
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| Synonyms: | HISTAMINE H1 | HRH1_RAT | Hrh1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 55716.35 |
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| Organism: | RAT |
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| Description: | HISTAMINE H1 HRH1 RAT::P31390 |
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| Residue: | 486 |
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| Sequence: | MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKC
ETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLR
SDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCF
RLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTT
DSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIM
AAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKK
ILHIRS
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| BDBM50111634 |
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| n/a |
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| Name | BDBM50111634 |
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| Synonyms: | 6-{2-[4-(3,4-Dichloro-benzyl)-piperazin-1-yl]-ethyl}-3-methyl-3H-benzothiazol-2-one | CHEMBL15601 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23Cl2N3OS |
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| Mol. Mass. | 436.398 |
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| SMILES | Cn1c2ccc(CCN3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)cc2sc1=O |
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| Structure | 
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